Patient FAQ

Is PAMP-immunotherapy restricted to particular forms of cancer ?

PAMP-immunotherapy is a general immune stimulatory method aimed at strengthening and amplifying an extant immune reaction against cancer cells, which is present in many if not most cancer patients. 

Even if there are several indications from experiments in cancer mice, that PAMP-therapy might have positive effects, often results in mice cannot be propagated into man. Are there results in humans ?  

First, we have to mention the old, often extraordinary results achieved by Coley and contemporaries in the years  1895-1936 in cancer patients (see "Healing Heat", amazon 2016). They used PAMP (see definitions and general FAQ) containing bacterial extracts, we use approved PAMP containing drugs. We are quite certain that PAMP substances from pathogens are the common denominator. Apart from different "PAMP vectors" we try to orient towards Coley's therapy recommendations.

Further there are anecdotal reports from cancer treatments using Vaccineurin in the 1960ies to 1980ies in Germany. Vaccineurin was a drug similar to Coley's preparation but not approved for cancer therapy. These results have never been formally published - they were done in private clinics on a sub-academic level - but healings even from aggressive cancers such as pancreatic cancer have been reported by witnesses. 

In newer times we have several positive reports using mistletoe extract - mistletoe lectin is a PAMP - in high dosage, multimodal settings, as well as other fever induction therapies (see case studies). These cases were not done according to the - more recent - PAMP-immunotherapy protocol, but presumably immune stimulatory effects were triggered by PAMP in all these cases. With PAMP-immunotherapy we apply several PAMP substances together rather than one in mistletoe therapy. We could induce remissions using PAMP-drugs (see our 2018 safety study), 

A cheap cancer treatment without severe adverse effects sounds too good to be true- Why is PAMP-immunotherapy not yet broadly established ? 

PAMP-immunotherapy is new. We have formally introduced the idea in 2016 and developed a defined treatment protocol in 2018. Several patients started treatment in 2018. Clinics where PAMP-immunotherapy is known are listed in the patients information leaflet

How expensive is PAMP-immunotherapy ? 

Drug costs for five weeks PAMP-immunotherapy are about 400-600 Euro (pharmacy OTC)  in Germany. In semi-stationary or stationary settings, costs for bed, nutrition and circulation monitoring add up. Private clinics in Germany charge about 300-350€/day for stationary setting. Refunding must be negotiated with the health insurance.

Can a general practitioner treat according to PAMP-immunotherapy ? 

In principle, yes. There should be a restroom and instruments for monitoring circulation. 

How does the treatment look like ? 

Using a selection of pharmaceutically approved drugs, we start with very low dosage applied subcutaneously on day one. The first week is dedicated to finding the correct dosage, which may be different from patient to patient. We increase dosage from day to day, to determine a fever inducing dose with a peak body temperature between 39C and 40C with fever coming down to normal within one day.  Then, PAMP are applied 2-3 times a week over the next 2-4 weeks. Patients appear with empty stomach in the morning to get an infusion of three PAMP drugs combined over 30-120 minutes. 

Usually fever peaks 2-5 hours after infusion and declines till evening. Often patients have a healthy appetite after treatment. Sometimes a few days after treatment patients report increased physical and mental power. 

Are severe adverse effect to be expected ? 

PAMP-immunotherapy safety is excellent. Over 523 applications in 131 patients no severe adverse event such as seizure, circulatory collaps, tumour lysis syndrome or allergic anaphylactic shock was observed. Mild flue-like symptoms such as nausea, vomitting, shills, back pain, headaches, weakness should be expected. Other possible side effects are listed in the patients information leaflet

Are three fever inductions per week over four weeks required ? 

Coley had the feeling that his successes correlated with number and short frequency of fever induction. Weak patients may benefit from  sub-febrile high-frequency vaccinations as well.

Can PAMP-immunotherapy be dangerous ?

To the best of our knowledge, among those 1200 or so patients treated by Coley and contemporaries, there never was an indication that disease progress accelerated. In some cases disease progress could not be slowed down, in many other disease progress could be slowed down, stopped, or even reversed into partial or complete remission.

Fever can be unpleasant and exhausting. It is not a walk in the park. If patients are weak, a less stringent regimen can be considered. Compared to chemotherapy, radiation, checkpoint inhibitors, PAMP-immunotherapy is not dangerous. 

What is the current status of PAMP immunotherapy?

The situation for patients is not easy. Health insurance financing is undefined, requiring negotiations and paperwork and treatment may result in private expense. There is a general hesitation to believe that a cheap and safe treatment can result in true healing, despite Coleys proof of principle. Patients have to understand how immunological cancer treatment works and must be exceptionally determined. They must interrupt their jobs for 4 weeks in a row for the first cycle and perhaps subsequent cycles of 1-2 weeks.

Would you do PAMP-immunotherapy to yourself ?

Sure enough.

 (C) Uwe Hobohm